Gene: RPP14

Alternate names for this Gene: P14

Gene Summary: This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p14.3

Description of this Gene: ribonuclease P/MRP subunit p14

Type of Gene: protein-coding

Gene: HTD2

Alternate names for this Gene: -

Gene Summary: This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved among animals. The upstream RPP14 gene is thought to be co-transcribed with this gene, and bicistronic transcripts may include open reading frames for both proteins.

Gene is located in Chromosome: 3

Location in Chromosome : 3p14.3

Description of this Gene: hydroxyacyl-thioester dehydratase type 2

Type of Gene: protein-coding

rs73081554 in RPP14;HTD2 gene and Rheumatoid Arthritis PMID 24532676 2015 High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

PMID 24390342 2014 Genetics of rheumatoid arthritis contributes to biology and drug discovery.

PMID 30423114 2019 Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.