Gene: RPRD1A

Alternate names for this Gene: HsT3101|P15RS

Gene Summary: This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16.

Gene is located in Chromosome: 18

Location in Chromosome : 18q12.2

Description of this Gene: regulation of nuclear pre-mRNA domain containing 1A

Type of Gene: protein-coding

rs28791905 in RPRD1A gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.