Gene: RPS6KC1

Alternate names for this Gene: RPK118|RSKL1|S6K-delta-1|S6PKh1|humS6PKh1

Gene Summary: Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria.

Gene is located in Chromosome: 1

Location in Chromosome : 1q32.3

Description of this Gene: ribosomal protein S6 kinase C1

Type of Gene: protein-coding

rs12040029 in RPS6KC1 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs17020562 in RPS6KC1 gene and Breast Carcinoma PMID 29059430 2017 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.

rs17020562 in RPS6KC1 gene and Malignant Childhood Neoplasm PMID 29059430 2017 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.

rs1187769 in RPS6KC1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.