Gene: RTEL1-TNFRSF6B
Alternate names for this Gene: -
Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring RTEL1 (regulator of telomere elongation helicase 1) and TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product.
Gene is located in Chromosome: 20
Location in Chromosome : 20q13.33
Description of this Gene: RTEL1-TNFRSF6B readthrough (NMD candidate)
Type of Gene: ncRNA
Gene: TNFRSF6B
Alternate names for this Gene: DCR3|DJ583P15.1.1|M68|M68E|TR6
Gene Summary: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.
Gene is located in Chromosome: 20
Location in Chromosome : 20q13.33
Description of this Gene: TNF receptor superfamily member 6b
Type of Gene: protein-coding
Gene: RTEL1
Alternate names for this Gene: C20orf41|DKCA4|DKCB5|NHL|PFBMFT3|RTEL
Gene Summary: This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene is located in Chromosome: 20
Location in Chromosome : 20q13.33
Description of this Gene: regulator of telomere elongation helicase 1
Type of Gene: protein-coding