Gene: RTEL1-TNFRSF6B

Alternate names for this Gene: -

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring RTEL1 (regulator of telomere elongation helicase 1) and TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product.

Gene is located in Chromosome: 20

Location in Chromosome : 20q13.33

Description of this Gene: RTEL1-TNFRSF6B readthrough (NMD candidate)

Type of Gene: ncRNA

Gene: TNFRSF6B

Alternate names for this Gene: DCR3|DJ583P15.1.1|M68|M68E|TR6

Gene Summary: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.

Gene is located in Chromosome: 20

Location in Chromosome : 20q13.33

Description of this Gene: TNF receptor superfamily member 6b

Type of Gene: protein-coding

rs909341 in RTEL1-TNFRSF6B;TNFRSF6B gene and Dermatitis, Atopic PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.