Gene: RUNDC3B

Alternate names for this Gene: RPIB9|RPIP9

Gene Summary:

Gene is located in Chromosome: 7

Location in Chromosome : 7q21.12

Description of this Gene: RUN domain containing 3B

Type of Gene: protein-coding

Gene: ABCB1

Alternate names for this Gene: ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1

Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

Gene is located in Chromosome: 7

Location in Chromosome : 7q21.12

Description of this Gene: ATP binding cassette subfamily B member 1

Type of Gene: protein-coding