Gene: RUNX1T1

Alternate names for this Gene: AML1-MTG8|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2

Gene Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 8

Location in Chromosome : 8q21.3

Description of this Gene: RUNX1 partner transcriptional co-repressor 1

Type of Gene: protein-coding