Gene: SAA2-SAA4

Alternate names for this Gene: -

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring serum amyloid A2 and serum amyloid A4 genes on chromosome 11. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.1

Description of this Gene: SAA2-SAA4 readthrough

Type of Gene: protein-coding

Gene: SAA2

Alternate names for this Gene: SAA|SAA1

Gene Summary: This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.1

Description of this Gene: serum amyloid A2

Type of Gene: protein-coding