Gene: SCARF2

Alternate names for this Gene: NSR1|SREC-II|SREC2|SRECRP-1|VDEGS

Gene Summary: The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene is located in Chromosome: 22

Location in Chromosome : 22q11.21

Description of this Gene: scavenger receptor class F member 2

Type of Gene: protein-coding

rs874100 in SCARF2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs387907086 in SCARF2 gene and Marden Walker like syndrome PMID 20887961 2010 Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome.