Gene: SCLY

Alternate names for this Gene: SCL|hSCL

Gene Summary: Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1050589.1, SRR1163655.520968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG MANE Ensembl match :: ENST00000254663.12/ ENSP00000254663.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.3

Description of this Gene: selenocysteine lyase

Type of Gene: protein-coding

Gene: UBE2F-SCLY

Alternate names for this Gene: -

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring UBE2F (ubiquitin-conjugating enzyme E2F) and SCLY (selenocysteine lyase) genes on chromosome 2. The read-through transcript is a candidate for non-sense mediated mRNA decay (NMD), and is unlikely to produce a protein product.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.3

Description of this Gene: UBE2F-SCLY readthrough (NMD candidate)

Type of Gene: ncRNA