Gene: SCML4

Alternate names for this Gene: dJ47M23.1

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6q21

Description of this Gene: Scm polycomb group protein like 4

Type of Gene: protein-coding

rs9400146 in SCML4 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs9486729 in SCML4 gene and Coronary Artery Disease PMID 29472232 2018 We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single nucleotide polymorphisms), rs9486729 (<i>SCML4</i> [Scm polycomb group protein-like 4]; odds ratio, 1.25; 95% CI, 1.17-1.34; <i>P</i>=3.51×10<sup>-11</sup>), rs17165136 (<i>THSD7A</i> [thrombospondin type 1 domain-containing 7A]; odds ratio 1.28; 95% CI, 1.21-1.35; <i>P</i><1.00×10<sup>-25</sup>), and rs852787 (<i>DAB1</i> [disabled-1]; odds ratio, 1.29; 95% CI, 1.21-1.38; <i>P</i>=2.02×10<sup>-14</sup>), associated with CAD with genome-wide significance.

rs6568490 in SCML4 gene and Lymphocyte Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs9400146 in SCML4 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs4945787 in SCML4 gene and Serum total cholesterol measurement PMID 31393916 2019 Genetically regulated gene expression underlies lipid traits in Hispanic cohorts.

rs9486689 in SCML4 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.