Gene: SCRIB

Alternate names for this Gene: CRIB1|SCRB1|SCRIB1|Vartul

Gene Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.3

Description of this Gene: scribble planar cell polarity protein

Type of Gene: protein-coding

rs1302482009 in SCRIB gene and NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO PMID 22095531 2012 Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.