Gene: SEC13
Alternate names for this Gene: D3S1231E|SEC13L1|SEC13R|npp-20
Gene Summary: The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found.
Gene is located in Chromosome: 3
Location in Chromosome : 3p25.3
Description of this Gene: SEC13 homolog, nuclear pore and COPII coat complex component
Type of Gene: protein-coding
Gene: GHRLOS
Alternate names for this Gene: GHRL-AS1|GHRLAS|NCRNA00068
Gene Summary: This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs.
Gene is located in Chromosome: 3
Location in Chromosome : 3p25.3
Description of this Gene: ghrelin opposite strand/antisense RNA
Type of Gene: ncRNA
Gene: GHRL
Alternate names for this Gene: MTLRP
Gene Summary: This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.
Gene is located in Chromosome: 3
Location in Chromosome : 3p25.3
Description of this Gene: ghrelin and obestatin prepropeptide
Type of Gene: protein-coding