Gene: SEC14L5

Alternate names for this Gene: PRELID4B

Gene Summary:

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.3

Description of this Gene: SEC14 like lipid binding 5

Type of Gene: protein-coding

Gene: PPL

Alternate names for this Gene: -

Gene Summary: The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.3

Description of this Gene: periplakin

Type of Gene: protein-coding

rs3852764 in SEC14L5;PPL gene and Malignant Neoplasms PMID 29299148 2017 Cancer risk susceptibility loci in a Swedish population.