Gene: SEL1L

Alternate names for this Gene: Hrd3|PRO1063|SEL1-LIKE|SEL1L1

Gene Summary: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 14

Location in Chromosome : 14q31.1

Description of this Gene: SEL1L adaptor subunit of ERAD E3 ubiquitin ligase

Type of Gene: protein-coding

rs11499034 in SEL1L gene and Tonometry PMID 29617998 2018 Genome-wide association analyses identify new loci influencing intraocular pressure.