Gene: SGSM2

Alternate names for this Gene: RUTBC1

Gene Summary: The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.3

Description of this Gene: small G protein signaling modulator 2

Type of Gene: protein-coding

rs4790333 in SGSM2 gene and Insulin measurement PMID 21873549 2011 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

PMID 23263489 2013 Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

rs898750 in SGSM2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.