Gene: SIAH2

Alternate names for this Gene: hSiah2

Gene Summary: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Gene is located in Chromosome: 3

Location in Chromosome : 3q25.1

Description of this Gene: siah E3 ubiquitin protein ligase 2

Type of Gene: protein-coding

rs6788895 in SIAH2 gene and Breast Carcinoma PMID 22951594 2012 A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.

rs6788895 in SIAH2 gene and Malignant neoplasm of breast PMID 22951594 2012 A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.