Gene: SIK1

Alternate names for this Gene: DEE30|MSK|SIK|SIK-1|SIK1B|SNF1LK

Gene Summary: This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30.

Gene is located in Chromosome: 21

Location in Chromosome : 21q22.3

Description of this Gene: salt inducible kinase 1

Type of Gene: protein-coding

rs76081789 in SIK1 gene and Allergic Reaction PMID 29083406 2017 Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

rs2006112 in SIK1 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.