Gene: SIN3A
Alternate names for this Gene: WITKOS
Gene Summary: The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Gene is located in Chromosome: 15
Location in Chromosome : 15q24.2
Description of this Gene: SIN3 transcription regulator family member A
Type of Gene: protein-coding
rs1567368243 in
SIN3A gene and
Autistic behavior
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1567368243 in
SIN3A gene and
Clinodactyly of the 5th finger
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1567368243 in
SIN3A gene and
Depressed nasal bridge
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1567368243 in
SIN3A gene and
Downward slant of palpebral fissure
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1555444885 in
SIN3A gene and
Dysmorphic features
PMID 22180641 2012 Further clinical and molecular delineation of the 15q24 microdeletion syndrome.
PMID 9620804 1998 Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.
PMID 27399968 2016 Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.
PMID 10801981 2000 The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.
PMID 15998811 2005 mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
PMID 10734093 2000 The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
PMID 12150998 2002 Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.
PMID 10022921 1999 A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast.
PMID 16055712 2005 The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.
PMID 24189169 2014 Sin3: insight into its transcription regulatory functions.
PMID 19505602 2009 Sin3: master scaffold and transcriptional corepressor.
PMID 25527279 2015 Inherited 15q24 microdeletion syndrome in twins and their father with phenotypic variability.
PMID 9799435 1998 The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability.
rs4886696 in
SIN3A gene and
Glomerular Filtration Rate
PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.
rs1567368243 in
SIN3A gene and
Long face
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1555444885 in
SIN3A gene and
Muscle hypotonia
PMID 27399968 2016 Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.
PMID 24189169 2014 Sin3: insight into its transcription regulatory functions.
PMID 16055712 2005 The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.
PMID 25527279 2015 Inherited 15q24 microdeletion syndrome in twins and their father with phenotypic variability.
PMID 15998811 2005 mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
PMID 19505602 2009 Sin3: master scaffold and transcriptional corepressor.
PMID 9620804 1998 Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.
PMID 22180641 2012 Further clinical and molecular delineation of the 15q24 microdeletion syndrome.
PMID 10801981 2000 The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.
PMID 12150998 2002 Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.
PMID 10734093 2000 The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
PMID 10022921 1999 A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast.
PMID 9799435 1998 The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability.
rs1567368243 in
SIN3A gene and
Poor school performance
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1567368243 in
SIN3A gene and
Small hand
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1567368243 in
SIN3A gene and
Thick ear helices
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.
rs1567368243 in
SIN3A gene and
WITTEVEEN-KOLK SYNDROME
PMID 30267900 2019 Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.