Gene: SIRT3
Alternate names for this Gene: SIR2L3
Gene Summary: SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control.
Gene is located in Chromosome: 11
Location in Chromosome : 11p15.5
Description of this Gene: sirtuin 3
Type of Gene: protein-coding
rs7104764 in
SIRT3 gene and
Age at menarche
PMID 25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
rs507139 in
SIRT3 gene and
Plexiform leiomyoma
PMID 30194396 2018 Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
PMID 31649266 2019 Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
rs507139 in
SIRT3 gene and
Uterine Fibroids
PMID 30194396 2018 Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
PMID 31649266 2019 Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.