Gene: SIRT4

Alternate names for this Gene: SIR2L4

Gene Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Gene is located in Chromosome: 12

Location in Chromosome : 12q24.23-q24.31

Description of this Gene: sirtuin 4

Type of Gene: protein-coding