Gene: SLC22A3

Alternate names for this Gene: EMT|EMTH|OCT3

Gene Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6q25.3

Description of this Gene: solute carrier family 22 member 3

Type of Gene: protein-coding

rs7758229 in SLC22A3 gene and Adenocarcinoma of large intestine PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs12194182 in SLC22A3 gene and Autistic Disorder PMID 22843504 2012 Individual common variants exert weak effects on the risk for autism spectrum disorders.

rs189821701 in SLC22A3 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs668871 in SLC22A3 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

rs3127574 in SLC22A3 gene and Body mass index PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7758229 in SLC22A3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs7758229 in SLC22A3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs7758229 in SLC22A3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs7758229 in SLC22A3 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs7758229 in SLC22A3 gene and Colorectal Carcinoma PMID 21242260 2011 Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.

rs7758229 in SLC22A3 gene and Colorectal Neoplasms PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs2048327 in SLC22A3 gene and Coronary Artery Disease PMID 23202125 2013 Large-scale association analysis identifies new risk loci for coronary artery disease.

PMID 24262325 2014 Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

PMID 19198611 2009 Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

rs2048327 in SLC22A3 gene and Coronary heart disease PMID 19198611 2009 Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

PMID 24262325 2014 Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

rs543159 in SLC22A3 gene and Glycine measurement PMID 30837465 2019 Assessing the causal association of glycine with risk of cardio-metabolic diseases.

rs1018234 in SLC22A3 gene and Lipoprotein (a) measurement PMID 28512139 2017 A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.

rs7758229 in SLC22A3 gene and Malignant neoplasm of large intestine PMID 21242260 2011 Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.

rs9364554 in SLC22A3 gene and Malignant neoplasm of prostate PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

rs7758229 in SLC22A3 gene and Malignant tumor of colon PMID 21242260 2011 We identified a novel locus on 6q26-q27 region (rs7758229 in SLC22A3, p = 7.92 × 10⁻⁹, OR of 1.28) that was significantly associated with distal colon cancer.

rs9364554 in SLC22A3 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs3123636 in SLC22A3 gene and Prostate carcinoma PMID 27262462 2016 Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.

PMID 25939597 2015 Two susceptibility loci identified for prostate cancer aggressiveness.

PMID 26034056 2015 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

rs1567441 in SLC22A3 gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

rs3105749 in SLC22A3 gene and Triglycerides measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs474513 in SLC22A3 gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.