Gene: SLC22A4

Alternate names for this Gene: DFNB60|OCTN1

Gene Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: solute carrier family 22 member 4

Type of Gene: protein-coding

rs6860806 in SLC22A4 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs419291 in SLC22A4 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.