Gene: SLC25A31

Alternate names for this Gene: AAC4|ANT 4|ANT4|SFEC35kDa

Gene Summary: The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 4

Location in Chromosome : 4q28.1

Description of this Gene: solute carrier family 25 member 31

Type of Gene: protein-coding

rs6534637 in SLC25A31 gene and Malignant neoplasm of testis PMID 21551455 2011 A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.

rs4834214 in SLC25A31 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.