Gene: SLX4

Alternate names for this Gene: BTBD12|FANCP|MUS312

Gene Summary: This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia.

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.3

Description of this Gene: SLX4 structure-specific endonuclease subunit

Type of Gene: protein-coding

rs7199766 in SLX4 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1567166544 in SLX4 gene and Fanconi Anemia PMID 19596235 2009 Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

PMID 19596236 2009 Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.