Gene: SNCA

Alternate names for this Gene: NACP|PARK1|PARK4|PD1

Gene Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4q22.1

Description of this Gene: synuclein alpha

Type of Gene: protein-coding

Gene: LOC105377329

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