Gene: SNCA-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: SNCA

Alternate names for this Gene: NACP|PARK1|PARK4|PD1

Gene Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4q22.1

Description of this Gene: synuclein alpha

Type of Gene: protein-coding

rs1372518 in SNCA-AS1;SNCA gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs7681440 in SNCA-AS1;SNCA gene and Lewy Body Disease PMID 29263008 2018 Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

rs1372519 in SNCA-AS1;SNCA gene and Parkinson Disease PMID 21738487 2011 Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

PMID 22438815 2012 Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.