Gene: SNX8

Alternate names for this Gene: Mvp1

Gene Summary:

Gene is located in Chromosome: 7

Location in Chromosome : 7p22.3

Description of this Gene: sorting nexin 8

Type of Gene: protein-coding

rs6461309 in SNX8 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs144787122 in SNX8 gene and Low density lipoprotein cholesterol measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs10950641 in SNX8 gene and Malignant Head and Neck Neoplasm PMID 29884837 2018 We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.

rs10950641 in SNX8 gene and Neuropathic pain PMID 29884837 2018 We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.

rs6461309 in SNX8 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs58921703 in SNX8 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.