Gene: SOS2

Alternate names for this Gene: NS9|SOS-2

Gene Summary: This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9.

Gene is located in Chromosome: 14

Location in Chromosome : 14q21.3

Description of this Gene: SOS Ras/Rho guanine nucleotide exchange factor 2

Type of Gene: protein-coding

rs72681869 in SOS2 gene and Birth Weight PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

rs72681869 in SOS2 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs72681869 in SOS2 gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1442962879 in SOS2 gene and NOONAN SYNDROME 9 PMID 25795793 2015 Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.

PMID 26173643 2015 Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.

rs869320687 in SOS2 gene and Noonan Syndrome 1 PMID 26173643 2015 Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.

rs147168872 in SOS2 gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs147168872 in SOS2 gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs72681869 in SOS2 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs61755579 in SOS2 gene and Tonometry PMID 30054594 2018 Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

PMID 29785010 2018 Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.

PMID 29617998 2018 Genome-wide association analyses identify new loci influencing intraocular pressure.

rs72681869 in SOS2 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.