Gene: SOX6

Alternate names for this Gene: HSSOX6|SOXD|TOLCAS

Gene Summary: This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.2

Description of this Gene: SRY-box transcription factor 6

Type of Gene: protein-coding

Gene: C11orf58

Alternate names for this Gene: IMAGE145052|SMAP

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.2

Description of this Gene: chromosome 11 open reading frame 58

Type of Gene: protein-coding

rs3809095 in SOX6;C11orf58 gene and Bone Density PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

rs376898975 in SOX6;C11orf58 gene and Reticulocyte count (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.