Gene: SP7
Alternate names for this Gene: OI11|OI12|OSX|osterix
Gene Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
Gene is located in Chromosome: 12
Location in Chromosome : 12q13.13
Description of this Gene: Sp7 transcription factor
Type of Gene: protein-coding
rs199673881 in
SP7 gene and
Body Height
PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.
rs10876432 in
SP7 gene and
Bone Density
PMID 19079262 2009 New sequence variants associated with bone mineral density.
PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
PMID 19801982 2009 Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
rs10876432 in
SP7 gene and
Bone Mineral Density Test
PMID 21927923 2012 Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects.
PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.