Gene: SPINT2
Alternate names for this Gene: DIAR3|HAI-2|HAI2|Kop|PB
Gene Summary: This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 19
Location in Chromosome : 19q13.2
Description of this Gene: serine peptidase inhibitor, Kunitz type 2
Type of Gene: protein-coding