Gene: SPOP

Alternate names for this Gene: BTBD32|NEDMACE|NEDMIDF|NSDVS1|NSDVS2|TEF2

Gene Summary: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.33

Description of this Gene: speckle type BTB/POZ protein

Type of Gene: protein-coding

Gene: LOC107984999

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rs1057519965 in SPOP;LOC107984999 gene and Adenocarcinoma of prostate PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519968 in SPOP;LOC107984999 gene and Malignant Uterine Corpus Neoplasm PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.