Gene: SPP1
Alternate names for this Gene: BNSP|BSPI|ETA-1|OPN
Gene Summary: The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 4
Location in Chromosome : 4q22.1
Description of this Gene: secreted phosphoprotein 1
Type of Gene: protein-coding
rs2853749 in
SPP1 gene and
Arthritis, Gouty
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
PMID 20884846 2010 Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
rs2853749 in
SPP1 gene and
Gout
PMID 20884846 2010 Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.