Gene: SPRED1

Alternate names for this Gene: LGSS|NFLS|PPP1R147|hSpred1|spred-1

Gene Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Gene is located in Chromosome: 15

Location in Chromosome : 15q14

Description of this Gene: sprouty related EVH1 domain containing 1

Type of Gene: protein-coding

Gene: LOC107984760

Alternate names for this Gene:

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rs7175472 in SPRED1;LOC107984760 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs7175472 in SPRED1;LOC107984760 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.