Gene: SPSB2

Alternate names for this Gene: GRCC9|SSB2

Gene Summary: This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31

Description of this Gene: splA/ryanodine receptor domain and SOCS box containing 2

Type of Gene: protein-coding

rs11064437 in SPSB2 gene and Adenocarcinoma of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and Colorectal Carcinoma PMID 26965516 2016 We identified 4 loci associated with CRC risk; P values for the most significant variant in each locus ranged from 3.92 × 10(-8) to 1.24 × 10(-12): 6p21.1 (rs4711689), 8q23.3 (rs2450115, rs6469656), 10q24.3 (rs4919687), and 12p13.3 (rs11064437).

rs11064437 in SPSB2 gene and Colorectal Neoplasms PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and Malignant neoplasm of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

rs11064437 in SPSB2 gene and Malignant tumor of colon PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.