Gene: STK39

Alternate names for this Gene: DCHT|PASK|SPAK

Gene Summary: This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.

Gene is located in Chromosome: 2

Location in Chromosome : 2q24.3

Description of this Gene: serine/threonine kinase 39

Type of Gene: protein-coding

rs6749447 in STK39 gene and Blood Pressure PMID 19114657 2009 From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

rs2390669 in STK39 gene and Body mass index PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.

rs2390669 in STK39 gene and Parkinson Disease PMID 22438815 2012 Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.