Gene: SUGCT

Alternate names for this Gene: C7orf10|DERP13|GA3|ORF19

Gene Summary: This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants.

Gene is located in Chromosome: 7

Location in Chromosome : 7p14.1

Description of this Gene: succinyl-CoA:glutarate-CoA transferase

Type of Gene: protein-coding

rs7809981 in SUGCT gene and Acne Vulgaris PMID 30542056 2018 Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne.

rs4379368 in SUGCT gene and Common Migraine PMID 23793025 2013 Genome-wide meta-analysis identifies new susceptibility loci for migraine.

rs10246797 in SUGCT gene and Fasting blood glucose measurement PMID 19060907 2009 Variants in MTNR1B influence fasting glucose levels.

rs137852860 in SUGCT gene and Glutaric Aciduria III PMID 23893049 2014 C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA.

PMID 18926513 2008 Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in c7orf10.

rs186166891 in SUGCT gene and Migraine Disorders PMID 27322543 2016 Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

PMID 23793025 2013 Genome-wide meta-analysis identifies new susceptibility loci for migraine.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs17621345 in SUGCT gene and Prostate carcinoma PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

rs3857747 in SUGCT gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs3857747 in SUGCT gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs17171703 in SUGCT gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs1203571 in SUGCT gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs2329877 in SUGCT gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.