Gene: SUOX

Alternate names for this Gene: -

Gene Summary: Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.2

Description of this Gene: sulfite oxidase

Type of Gene: protein-coding

Gene: RAB5B

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.2

Description of this Gene: RAB5B, member RAS oncogene family

Type of Gene: protein-coding

rs705699 in SUOX;RAB5B gene and Adult onset asthma PMID 31036433 2019 Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

rs705699 in SUOX;RAB5B gene and Blood basophil count (lab test) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs705699 in SUOX;RAB5B gene and Childhood asthma PMID 31036433 2019 Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

rs705699 in SUOX;RAB5B gene and Diabetes Mellitus, Insulin-Dependent PMID 31152121 2019 We identified four T1D risk loci reaching genome-wide significance in the Chinese Han population, including two novel loci, rs4320356 near <i>BTN3A1</i> (odds ratio [OR] 1.26, <i>P</i> = 2.70 × 10<sup>-8</sup>) and rs3802604 in <i>GATA3</i> (OR 1.24, <i>P</i> = 2.06 × 10<sup>-8</sup>), and two previously reported loci, rs1770 in MHC (OR 4.28, <i>P</i> = 2.25 × 10<sup>-232</sup>) and rs705699 in <i>SUOX</i> (OR 1.46, <i>P</i> = 7.48 × 10<sup>-20</sup>).

rs705699 in SUOX;RAB5B gene and Eosinophil count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs772920 in SUOX;RAB5B gene and Forced expiratory volume function PMID 30061609 2018 Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

rs772920 in SUOX;RAB5B gene and Hypothyroidism PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs705702 in SUOX;RAB5B gene and Polycystic Ovary Syndrome PMID 22885925 2012 Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.