Gene: TACC2

Alternate names for this Gene: AZU-1|ECTACC

Gene Summary: Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10q26.13

Description of this Gene: transforming acidic coiled-coil containing protein 2

Type of Gene: protein-coding

rs2253762 in TACC2 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs11200391 in TACC2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs17103138 in TACC2 gene and Myopia, Degenerative PMID 23049088 2012 A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.

rs58356853 in TACC2 gene and Opioid-Related Disorders PMID 31250797 2019 Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry.

rs192386132 in TACC2 gene and Weight Gain PMID 31560688 2019 Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.