Gene: TAFA1

Alternate names for this Gene: FAM19A1|TAFA-1

Gene Summary: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.

Gene is located in Chromosome: 3

Location in Chromosome : 3p14.1

Description of this Gene: TAFA chemokine like family member 1

Type of Gene: protein-coding

rs1491744 in TAFA1 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs1858242 in TAFA1 gene and Physical Activity Measurement PMID 30531941 2018 GWAS identifies 14 loci for device-measured physical activity and sleep duration.

rs1491744 in TAFA1 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.