Gene: TAFA2

Alternate names for this Gene: FAM19A2|TAFA-2

Gene Summary: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.

Gene is located in Chromosome: 12

Location in Chromosome : 12q14.1

Description of this Gene: TAFA chemokine like family member 2

Type of Gene: protein-coding

rs11174202 in TAFA2 gene and Anorexia Nervosa PMID 28494655 2017 Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.

PMID 30087453 2018 Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.

rs2198776 in TAFA2 gene and Body mass index PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11174267 in TAFA2 gene and Chronic Obstructive Airway Disease PMID 24621683 2014 Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs17713040 in TAFA2 gene and Diastolic blood pressure PMID 29455858 2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

rs11174202 in TAFA2 gene and Obsessive-Compulsive Disorder PMID 30087453 2018 Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.

rs2198776 in TAFA2 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs11174267 in TAFA2 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.