Gene: TAGLN

Alternate names for this Gene: SM22|SM22-alpha|SMCC|TAGLN1|WS3-10

Gene Summary: This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.3

Description of this Gene: transgelin

Type of Gene: protein-coding

Gene: LOC100652768

Alternate names for this Gene:

Gene Summary:

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rs74949440 in TAGLN;LOC100652768 gene and Breast Carcinoma PMID 29059430 2017 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.

rs74949440 in TAGLN;LOC100652768 gene and Malignant Childhood Neoplasm PMID 29059430 2017 Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.