Gene: TCF7L1

Alternate names for this Gene: TCF-3|TCF3

Gene Summary: This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

Gene is located in Chromosome: 2

Location in Chromosome : 2p11.2

Description of this Gene: transcription factor 7 like 1

Type of Gene: protein-coding

rs11904127 in TCF7L1 gene and Bone Density PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

rs6547598 in TCF7L1 gene and Cervix carcinoma PMID 30412241 2019 Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.

rs6547599 in TCF7L1 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs62162674 in TCF7L1 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.