Gene: TCN1

Alternate names for this Gene: HC|TC-1|TC1|TCI

Gene Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells.

Gene is located in Chromosome: 11

Location in Chromosome : 11q12.1

Description of this Gene: transcobalamin 1

Type of Gene: protein-coding

rs34324219 in TCN1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs34324219 in TCN1 gene and VITAMIN B12 MEASUREMENT PMID 25147783 2014 Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.

PMID 28334792 2017 GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.

PMID 19744961 2009 Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.