Gene: TDP2

Alternate names for this Gene: AD022|EAP2|EAPII|TTRAP|dJ30M3.3|hTDP2

Gene Summary: This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.3

Description of this Gene: tyrosyl-DNA phosphodiesterase 2

Type of Gene: protein-coding

rs3181245 in TDP2 gene and Adenocarcinoma of large intestine PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181238 in TDP2 gene and Alkaline phosphatase measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs3181245 in TDP2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and Colorectal Carcinoma PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and Colorectal Neoplasms PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and Endometrial Neoplasms PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and Malignant neoplasm of large intestine PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

rs3181245 in TDP2 gene and Malignant tumor of colon PMID 26621817 2015 Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.