Gene: TGFBRAP1

Alternate names for this Gene: TRAP-1|TRAP1|VPS3

Gene Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes.

Gene is located in Chromosome: 2

Location in Chromosome : 2q12.1-q12.2

Description of this Gene: transforming growth factor beta receptor associated protein 1

Type of Gene: protein-coding

rs2679894 in TGFBRAP1 gene and Age at menarche PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2679894 in TGFBRAP1 gene and Age at menopause PMID 29773799 2018 Elucidating the genetic architecture of reproductive ageing in the Japanese population.

rs4851057 in TGFBRAP1 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs62154720 in TGFBRAP1 gene and Intelligence PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs2460255 in TGFBRAP1 gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.

rs62154720 in TGFBRAP1 gene and Schizophrenia PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs62154720 in TGFBRAP1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.