Gene: TH2LCRR

Alternate names for this Gene: TH2-LCR

Gene Summary:

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: T helper type 2 locus control region associated RNA

Type of Gene: ncRNA

Gene: IL13

Alternate names for this Gene: IL-13|P600

Gene Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: interleukin 13

Type of Gene: protein-coding

rs1295686 in TH2LCRR;IL13 gene and Allergic Reaction PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs115008099 in TH2LCRR;IL13 gene and Asthma PMID 31619474 2019 Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

PMID 21907864 2011 Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.

PMID 20860503 2010 A large-scale, consortium-based genomewide association study of asthma.

PMID 22561531 2012 Genome-wide association study to identify genetic determinants of severe asthma.

rs1295685 in TH2LCRR;IL13 gene and Childhood asthma PMID 29273806 2018 Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

rs12188917 in TH2LCRR;IL13 gene and Dermatitis, Atopic PMID 26482879 2015 Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

PMID 23886662 2013 A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.

rs1295685 in TH2LCRR;IL13 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1295685 in TH2LCRR;IL13 gene and Psoriasis PMID 23143594 2012 Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

rs1295685 in TH2LCRR;IL13 gene and Psoriasis vulgaris PMID 26626624 2015 Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.

rs115008099 in TH2LCRR;IL13 gene and Respiratory Tract Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.