Gene: THEMIS

Alternate names for this Gene: C6orf190|C6orf207|GASP|SPOT|TSEPA

Gene Summary: This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 6

Location in Chromosome : 6q22.33

Description of this Gene: thymocyte selection associated

Type of Gene: protein-coding

rs4897233 in THEMIS gene and Celiac Disease PMID 25920553 2016 Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.