Gene: TICAM1

Alternate names for this Gene: IIAE6|MyD88-3|PRVTIRB|TICAM-1|TRIF

Gene Summary: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.3

Description of this Gene: toll like receptor adaptor molecule 1

Type of Gene: protein-coding

rs146550489 in TICAM1 gene and ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 PMID 22105173 2011 Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.

rs4807000 in TICAM1 gene and Vitiligo PMID 27723757 2016 Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.

PMID 22561518 2012 Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.